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KMID : 0375320000220020251
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Journal of Clinical Pathology and Quality Control
2000 Volume.22 No. 2 p.251 ~ p.254
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Analytical Evaluation for Serum Digoxin Measurements
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Kang Moon-Soo
Kim Sang-Jin
Nahm Chung-Hyun
Choi Jong-Won
Pai Soo-Hwan
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Abstract
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Background : We evaluated the ACS:180"1 (Chiron Diagnostics, MA, USA) and Vitros 250"" (Johnson & Johnson Clinical Diagnostics, Inc., NY, USA) in the measurement of digoxin levels and compaired its results to those of the TDxFLx (Abbott Laboratories, IL, USA) nationwide used for therapeutic drug monitoring (TDM) in order to assess the utility of the ACS:180", and Vitros 25011, as TDM instruments.
Methods : 48 candidates for TDM were randomly chosen to measure digoxin using the TDxFLx ", ACS:180 and Vitros 250"´. The within-run and between-run precisions of 3 instruments were respectively determined for digoxin. Correlations between TDxFLx and ACS: 180"1, and between TDxFLx" and Vitros 250`" also were respectively determined for quantitative measurement of digoxin.
Results : The coefficients of variation (CV) for the within-run of the TDxFLx were 7.40, 3.56, 4.28% for low, medium, high concentration, respectively, and for the CVs of between-run were 9.93, 6.66, 4.76%, respectively. The CVs for the within-run of ACS: 180 were 2.46% for medium concentration, and for between-run were 3.86%. The CVs for the within-run of Vitros 250"1 were 3.89, 2.32% for Vitros Performance Verifier (PV) I and II, and for between-run were 3.66, 2.36%. Correlations between TDxFLx´" and ACS:180 and between TDxFLx and Vitros 250´" also were 0.9831, 0.9692 for measurement of digoxin, respectively.
Conclusion : The TDxFLx´", ACS: 180,1 and Vitros 250"` were proved to be good precisions for quantitative analysis of digoxin. The results obtained by ACS: 180"° and Vitros 250"t correlate well with those of the TDxFLx".
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KEYWORD
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Therapeutic drug monitoring, TDxFLx(®), ACS:180(®), Vitros 250(®) Digoxin
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